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Early-onset Gastric Cancer

Jurisdiction:

South Korea

Organ System:

Stomach

Funding Organization:

  • Korean Ministry of Science and ICT (MSIT), S. Korea

Research Organizations:

  • Korea University, S. Korea
  • DGIST, S. Korea
  • Ewha Womans University, S. Korea
  • Hanyang University, S. Korea
  • Korea Institute of Science and Technology, S. Korea
  • National Cancer Center, S. Korea

Principal Investigators:

  • Daehee Hwang
  • Sang-Won Lee
  • Sanghyuk Lee
  • Eunok Paek
  • Hark Kyun Kim
  • Eun Gyeong Yang

Publication:

External Link:

We report proteogenomic analysis of diffuse gastric cancers (GCs) in young populations. Phosphoproteome data elucidated signaling pathways associated with somatic mutations based on mutation-phosphorylation correlations. Moreover, correlations between mRNA and protein abundances provided potential oncogenes and tumor suppressors associated with patient survival. Furthermore, integrated clustering of mRNA, protein, phosphorylation, and N-glycosylation data identified four subtypes of diffuse GCs. Distinguishing these subtypes was possible by proteomic data. Four subtypes were associated with proliferation, immune response, metabolism, and invasion, respectively; and associations of the subtypes with immune- and invasion-related pathways were identified mainly by phosphorylation and N-glycosylation data. Therefore, our proteogenomic analysis provides additional information beyond genomic analyses, which can improve understanding of cancer biology and patient stratification in diffuse GCs.

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