Jurisdiction:
South Korea
Organ System:
Stomach
Funding Organization:
- Korean Ministry of Science and ICT (MSIT), S. Korea
Research Organizations:
- Korea University, S. Korea
- DGIST, S. Korea
- Ewha Womans University, S. Korea
- Hanyang University, S. Korea
- Korea Institute of Science and Technology, S. Korea
- National Cancer Center, S. Korea
Principal Investigators
:- Daehee Hwang
- Sang-Won Lee
- Sanghyuk Lee
- Eunok Paek
- Hark Kyun Kim
- Eun Gyeong Yang
Publication:
External Link:
We report proteogenomic analysis of diffuse gastric cancers (GCs) in young populations. Phosphoproteome data elucidated signaling pathways associated with somatic mutations based on mutation-phosphorylation correlations. Moreover, correlations between mRNA and protein abundances provided potential oncogenes and tumor suppressors associated with patient survival. Furthermore, integrated clustering of mRNA, protein, phosphorylation, and N-glycosylation data identified four subtypes of diffuse GCs. Distinguishing these subtypes was possible by proteomic data. Four subtypes were associated with proliferation, immune response, metabolism, and invasion, respectively; and associations of the subtypes with immune- and invasion-related pathways were identified mainly by phosphorylation and N-glycosylation data. Therefore, our proteogenomic analysis provides additional information beyond genomic analyses, which can improve understanding of cancer biology and patient stratification in diffuse GCs.
