Jurisdiction:
United States
Organ System:
Brain
Funding Organization:
- National Cancer Institute, USA
Research Organizations:
- Icahn School of Medicine at Mount Sinai, USA
- Children's Hospital of Philadelphia, USA
- Fred Hutchinson Cancer Research Center, USA
- University of Miami Miller School of Medicine, USA
- University of Miami, USA
- Memorial Sloan Kettering Cancer Center, USA
- Harvard Medical School, USA
- Pacific Northwest National Laboratory, USA
- Broad Institute of MIT and Harvard, USA
- Washington University in St. Louis, USA
- George Washington University School of Medicine, USA
- Baylor College of Medicine, USA
- National Cancer Institute, USA
Principal Investigators
:- Pei Wang
- Brian Rood
- Phillip B Storm
- Adam C Resnick
Publication:
External Link:
We report a comprehensive proteogenomics analysis, including whole-genome sequencing, RNA sequencing, and proteomics and phosphoproteomics profiling, of 218 tumors across 7 histological types of childhood brain cancer: low-grade glioma (n = 93), ependymoma (32), high-grade glioma (25), medulloblastoma (22), ganglioglioma (18), craniopharyngioma (16), and atypical teratoid rhabdoid tumor (12). Proteomics data identify common biological themes that span histological boundaries, suggesting that treatments used for one histological type may be applied effectively to other tumors sharing similar proteomics features. Immune landscape characterization reveals diverse tumor microenvironments across and within diagnoses. Proteomics data further reveal functional effects of somatic mutations and copy number variations (CNVs) not evident in transcriptomics data. Kinase-substrate association and co-expression network analysis identify important biological mechanisms of tumorigenesis. This is the first large-scale proteogenomics analysis across traditional histological boundaries to uncover foundational pediatric brain tumor biology and inform rational treatment selection.