Pediatric Brain Cancer – USA


Jurisdiction:

United States

Organ System:

Brain

Funding Organization:

  • National Cancer Institute, USA

Research Organizations:

  • Baylor College of Medicine, USA
  • Broad Institute of MIT and Harvard, USA
  • Children's Hospital of Philadelphia, USA
  • Fred Hutchinson Cancer Research Center, USA
  • George Washington University School of Medicine, USA
  • Harvard Medical School, USA
  • Icahn School of Medicine at Mount Sinai, USA
  • Memorial Sloan Kettering Cancer Center
  • National Cancer Institute, USA
  • Pacific Northwest National Laboratory, USA
  • University of Miami
  • University of Miami Miller School of Medicine
  • Washington University in St. Louis, USA

Principal Investigators:

  • Adam C Resnick
  • Brian Rood
  • Pei Wang
  • Phillip B Storm

Publication:

External Link:


We report a comprehensive proteogenomics analysis, including whole-genome sequencing, RNA sequencing, and proteomics and phosphoproteomics profiling, of 218 tumors across 7 histological types of childhood brain cancer: low-grade glioma (n = 93), ependymoma (32), high-grade glioma (25), medulloblastoma (22), ganglioglioma (18), craniopharyngioma (16), and atypical teratoid rhabdoid tumor (12). Proteomics data identify common biological themes that span histological boundaries, suggesting that treatments used for one histological type may be applied effectively to other tumors sharing similar proteomics features. Immune landscape characterization reveals diverse tumor microenvironments across and within diagnoses. Proteomics data further reveal functional effects of somatic mutations and copy number variations (CNVs) not evident in transcriptomics data. Kinase-substrate association and co-expression network analysis identify important biological mechanisms of tumorigenesis. This is the first large-scale proteogenomics analysis across traditional histological boundaries to uncover foundational pediatric brain tumor biology and inform rational treatment selection.

 

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