International Cancer Proteogenome Consortium
The International Cancer Proteogenome Consortium (ICPC), is a voluntary scientific organization that provides a forum for collaboration among some of the world’s leading cancer and proteogenomic research centers. Catalyzed by the effort of the Cancer Moonshot to encourage international cooperation and investments among nations in cancer research and care, as well as new efforts in precision medicine, the International Cancer Proteogenome Consortium (ICPC) was launched in late 2016. The ICPC brings together more than a dozen countries to study the application of proteogenomic analysis in predicting cancer treatment success and to share data and results with researchers worldwide, hastening progress for patients.
Early-onset Breast Cancer
System:
Breast
Jurisdiction:
South Korea
Organ System: Breast
Jurisdiction: South Korea
Comprehensive genomic, transcriptomic, proteomic, and phosphoproteomic characterization of 139 treatment-naive early-onset breast cancers.
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Endometrial Carcinoma
System:
Uterus
Jurisdiction:
United States
Organ System: Uterus
Jurisdiction: United States
Proteogenomic study using 138 endometrial carcinoma and 20 normal endometrial tissue identified potential immunotherapeutic targets and suggested a potential role for metformin in non-diabetic patients with elevated MYC activity.
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High Grade Gliomas
System:
Brain
Jurisdiction:
United States
Organ System: Brain
Jurisdiction: United States
Integrative proteogenomic, metabolomic, and lipidomic analyses on 228 tumors (212 GBM and 16 grade 4 IDH-mutant astrocytoma), including 28 at recurrence, plus 18 normal brain samples and 14 brain metastases as comparators,
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Rare Kidney Cancer
System:
Kidney
Jurisdiction:
United States
Organ System: Kidney
Jurisdiction: United States
Multi-omics analyses of 48 non-ccRCCs compared with 103 ccRCCs reveal proteogenomic, phosphorylation, glycosylation, and metabolic aberrations in RCC subtypes and expands our knowledge of proteogenomic signatures, biomarkers, and potential therapeutic targets in non-ccRCC.
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Lung Adenocarcinoma
System:
Lung
Jurisdiction:
South Korea
Organ System: Lung
Jurisdiction: South Korea
Proteogenomic characterization of 141 Asian never-smoker lung adenocarcinoma cases reveled prognostic markers and proposed potential treatment in this population, which currently lacks effective targeted therapies.
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Glioblastoma
System:
Brain
Jurisdiction:
South Korea
Organ System: Brain
Jurisdiction: South Korea
An integrative proteogenomic analysis of 123 longitudinal glioblastoma pairs and identification of a highly proliferative cellular state at diagnosis and replacement by activation of neuronal transition and synaptogenic pathways in recurrent tumors.
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Prostate Cancer
System:
Prostate
Jurisdiction:
Australia
Organ System: Prostate
Jurisdiction: Australia
Proteomic, differential expression, machine learning, and survival analyses were conducted on 1,348 matched tumor and benign samples from 278 patients. This comprehensive study identified candidate biomarkers in patients with recurrence and established an 18-protein signature as prognostic markers.
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Small Cell Lung Cancer
System:
Lung
Jurisdiction:
China
Organ System: Lung
Jurisdiction: China
Comprehensive proteogenomic characterization of small cell lung cancer using paired tumors and adjacent lung tissues from 112 treatment-naïve patients.
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Cholangiocarcinoma
System:
Bile Duct
Jurisdiction:
South Korea
Organ System: Bile Duct
Jurisdiction: South Korea
In-depth analysis of genomic, transcriptomic, proteomic, and phosphoproteomic profiles in 102 treatment-naive intrahepatic cholangiocarcinoma (iCC) reveals promising therapeutic opportunities.
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Liver Cancer Organoids
System:
Liver
Jurisdiction:
China
Organ System: Liver
Jurisdiction: China
Establishment of a patient-derived liver cancer organoid biobank (LICOB) that comprehensively represents the histological and molecular characteristics of various liver cancer types as determined by multiomics profiling, including genomic, epigenomic, transcriptomic, and proteomic analysis.
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Pancreatic Ductal Adenocarcinoma
System:
Pancreas
Jurisdiction:
South Korea
Organ System: Pancreas
Jurisdiction: South Korea
Comprehensive genomic, transcriptomic, proteomic, and phosphoproteomic characterization of 196 treatment-naive PDAC tissue and blood samples.
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CCRCC heterogeneity
System:
Kidney
Jurisdiction:
United States
Organ System: Kidney
Jurisdiction: United States
Integrative histopathologic, proteogenomic, and metabolomic analyses on 305 ccRCC tumor segments and 166 paired adjacent normal tissues from 213 cases.
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Intrahepatic Cholangiocarcinoma
System:
Liver
Jurisdiction:
China
Organ System: Liver
Jurisdiction: China
Proteogenomic characterization of intrahepatic cholangiocarcinoma (iCCA) using paired tumor and adjacent liver tissues from 262 patients.
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Cutaneous Melanoma
System:
Skin
Jurisdiction:
Sweden
Organ System: Skin
Jurisdiction: Sweden
First study is to map the protein levels in malignant melanoma tumor samples, focused on in-depth histopathology coupled to proteome characterization. The protein levels and localization were determin...
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Pancreatic Ductal Adenocarcinoma
System:
Pancreas
Jurisdiction:
United States
Organ System: Pancreas
Jurisdiction: United States
Comprehensive genomic, epigenomic, transcriptomic, global proteomic, phosphoproteomic, and glycopreomic analysis of 140 pancreatic tumors, 67 NATs, and 9 normal ducts.
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Lung Squamous Cell Carcinoma
System:
Lung
Jurisdiction:
United States
Organ System: Lung
Jurisdiction: United States
Comprehensive genomic, epigenomic, transcriptomic, protein abundance, phosphorylation, acetylation, and ubiquitination analysis of 108 LSCCs and 99 paired NTAs.
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Glioblastoma Multiforme
System:
Brain
Jurisdiction:
United States
Organ System: Brain
Jurisdiction: United States
Comprehensive genomic, epigenomic, transcriptomic, protein abundance, phosphorylation, acetylation, and metabolomic analysis of 99 glioblastoma and 10 unmatched normal brain samples.
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Pediatric Brain Cancer
System:
Brain
Jurisdiction:
United States
Organ System: Brain
Jurisdiction: United States
Comprehensive genomic, transcriptomic, proteomic, and phosphoproteomic characterization of of 218 tumors across 7 histological types of childhood brain cancer
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Breast Cancer
System:
Breast
Jurisdiction:
United States
Organ System: Breast
Jurisdiction: United States
Comprehensive genomic, transcriptomic, proteomic, phosphoproteomic, and acetylproteomic characterization of 122 treatment-naive primary breast cancers.
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HPV-negative HNSCC
System:
Head and Neck
Jurisdiction:
United States
Organ System: Head and Neck
Jurisdiction: United States
Comprehensive genomic, epigenomic, transcriptomic, proteomic, and phosphoproteomic characterization of patient-matched tumor and NAT from 110 treatment-naive patients with HPV-negative head and neck squamous cell carcinoma.
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Oral Squamous Cell Carcinoma
System:
Head and Neck
Jurisdiction:
Taiwan
Organ System: Head and Neck
Jurisdiction: Taiwan
Comprehensive and systems-based interrogation of mutational landscapes and their pathological consequences in Oral squamous cell carcinoma patients from Taiwan.
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HBV+ Hepatocellular Carcinoma
System:
Liver
Jurisdiction:
China
Organ System: Liver
Jurisdiction: China
Proteogenomics analysis of paired tumor and non-tumor liver tissues from 159 HCC patients with HBV infection from China.
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Lung Adenocarcinoma
System:
Lung
Jurisdiction:
Taiwan
Organ System: Lung
Jurisdiction: Taiwan
Genomic, transcriptomic, protein abundance and phosphorylation data of patient-matched tumor and NAT from 103 treatment-naive patients with lung adenocarcinoma from Taiwan.
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Early-onset Gastric Cancer
System:
Stomach
Jurisdiction:
South Korea
Organ System: Stomach
Jurisdiction: South Korea
Proteogenomic analysis of diffuse gastric cancers (DGC) in a young population. Genomic, transcriptomic, protein abundance, phosphorylation and glycosylation in paired tumor and adjacent normal tissues from 80 patients.
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Colon Adenocarcinoma
System:
Intestine
Jurisdiction:
United States
Organ System: Intestine
Jurisdiction: United States
Comprehensive genomic, transcriptomic, protein abundance and phosphorylation analysis of prospectively collected tumor and paired normal adjacent tissues from 110 colon cancer patients .
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Ovarian High-Grade Serous Cancer
System:
Ovary
Jurisdiction:
United States
Organ System: Ovary
Jurisdiction: United States
Comprehensive genomic, transcriptomic, protein abundance and phosphorylation analysis of prospectively collected tissues from 83 patients with ovarian high-grade serous carcinoma (HGSC) samples and appropriate normal precursor tissue samples (fallopian tube). Integration of proteomic and glycoproteomic analysis of 83 HGSC and 23 non-tumor tissues.
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Lung Adenocarcinoma
System:
Lung
Jurisdiction:
United States
Organ System: Lung
Jurisdiction: United States
Comprehensive genomic, epigenomic, transcriptomic, protein abundance, phosphorylation and acetylation analysis of lung adenocarcinomas and paired normal adjacent tissues from 110 patients of diverse smoking status and country of origin.
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Endometrial Carcinoma
System:
Uterus
Jurisdiction:
United States
Organ System: Uterus
Jurisdiction: United States
Comprehensive genomic, epigenomic, transcriptomic, protein abundance, phosphorylation and acetylation analysis of 95 prospectively collected endometrial carcinomas, comprising 83 endometrioid and 12 serous tumors.
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Clear Cell Renal Cell Carcinoma
System:
Kidney
Jurisdiction:
United States
Organ System: Kidney
Jurisdiction: United States
Comprehensive genomic, epigenomic, transcriptomic, proteomic, and phosphoproteomic characterization of 103 treatment-naive ccRCC and paired normal adjacent tissue samples.
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